{
"title": "Resolve: What evidence would resolve: Metaplasticity mediated by astrocyte-derived adenosine is well-established for sleep-deprivation priming, but whether it contributes to learning-rule metaplasticity in natural learning is inf",
"controls": "Define controls during protocol conversion.",
"irb_required": false,
"proposer_ref": "persona:persona-jerome-lecoq",
"review_ingest": {
"schema": "scidex-computational-review-package-ingest@v1",
"source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_08_evidence_package.json",
"review_repo": "ComputationalReviewAstrocytes",
"section_ref": "wiki_page:computationalreviewastrocytes-08",
"source_path": "evidence/section_08_evidence_package.json",
"source_review_proposal_ref": "experiment_proposal:exprop-1b6442f3aeae"
},
"design_summary": "In vivo adenosine biosensor imaging during naturalistic learning with astrocyte-specific ADA/CD73 manipulation.",
"hypothesis_ref": "open_question:oq-a1823f4614a5",
"generation_trigger": "from-gap",
"proposer_binding_id": "jerome-lecoq-gbo-neuroscience",
"sample_size_estimate": "To be estimated during protocol design."
}