Forge Tools iuphar_pharmacology

iuphar_pharmacology read

scidex.forge.iuphar_pharmacology

Query the IUPHAR/BPS Guide to Pharmacology (GtoPdb) for drug target classification and approved ligand lists. For a single target name, returns the GtoPdb target ID, target family, HGNC gene symbol, and a list of curated ligands with action type (Agonist/Antagonist/Inhibitor), median affinity (pKd/pKi), and INN/generic name. GtoPdb is the gold standard for GPCRs, ion channels, nuclear receptors, and transporters — receptor families not deeply covered by DGIdb or PharmGKB. Set approved_only=True (default) to restrict to FDA/EMA-approved drugs. Not-found targets set not_found=True — no exception raised. API: guidetopharmacology.org/services — public, no auth required.

HTTP: POST /api/scidex/forge/iuphar_pharmacology

Invoke

Calls scidex.tool.invoke on the substrate with this tool name. Edit the JSON below — it must match the input schema. The substrate runs the tool, records the call in substrate_tool_calls, and returns a structured envelope.

Sign in to invoke this tool. Schema and curl snippet are visible to anyone.

Schemas

Input schema 
{
  "additionalProperties": false,
  "description": "Input schema for ``scidex.forge.iuphar_pharmacology``.",
  "properties": {
    "target_name": {
      "description": "Drug target name to look up in GtoPdb. May be a receptor name (e.g. '5-HT2A receptor'), gene symbol (e.g. 'HTR2A'), or common abbreviation (e.g. 'D2'). GtoPdb name search is case-insensitive.",
      "title": "Target Name",
      "type": "string"
    },
    "approved_only": {
      "default": true,
      "description": "If True (default), return only ligands that are approved drugs (FDA/EMA/other regulatory approval). If False, include all curated ligands including investigational compounds.",
      "title": "Approved Only",
      "type": "boolean"
    },
    "limit": {
      "default": 10,
      "description": "Maximum number of ligands to return. Default 10; maximum 100.",
      "maximum": 100,
      "minimum": 1,
      "title": "Limit",
      "type": "integer"
    }
  },
  "required": [
    "target_name"
  ],
  "title": "ForgeIUPHARPharmacologyIn",
  "type": "object"
}
Output schema 
{
  "$defs": {
    "IUPHARLigand": {
      "description": "One ligand–target interaction record from GtoPdb.",
      "properties": {
        "ligand_id": {
          "description": "GtoPdb ligand ID.",
          "title": "Ligand Id",
          "type": "integer"
        },
        "name": {
          "description": "Ligand name as curated in GtoPdb.",
          "title": "Name",
          "type": "string"
        },
        "ligand_type": {
          "description": "Ligand type (e.g. 'Small molecule', 'Peptide', 'Antibody', 'Inorganic').",
          "title": "Ligand Type",
          "type": "string"
        },
        "action": {
          "description": "Pharmacological action (e.g. 'Agonist', 'Antagonist', 'Inhibitor', 'Partial agonist', 'Inverse agonist'). Non-empty.",
          "title": "Action",
          "type": "string"
        },
        "affinity_median": {
          "anyOf": [
            {
              "type": "number"
            },
            {
              "type": "null"
            }
          ],
          "default": null,
          "description": "Median affinity value in -log(mol/L) units (pKd, pKi, or pIC50). None if not recorded in GtoPdb.",
          "title": "Affinity Median"
        },
        "inn_name": {
          "anyOf": [
            {
              "type": "string"
            },
            {
              "type": "null"
            }
          ],
          "default": null,
          "description": "INN (International Non-proprietary Name / generic name), if known.",
          "title": "Inn Name"
        }
      },
      "required": [
        "ligand_id",
        "name",
        "ligand_type",
        "action"
      ],
      "title": "IUPHARLigand",
      "type": "object"
    }
  },
  "description": "Response shape for ``scidex.forge.iuphar_pharmacology``.",
  "properties": {
    "target_name": {
      "description": "Canonical GtoPdb target name (as curated).",
      "title": "Target Name",
      "type": "string"
    },
    "target_id": {
      "anyOf": [
        {
          "type": "integer"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "GtoPdb target ID.",
      "title": "Target Id"
    },
    "target_family": {
      "anyOf": [
        {
          "type": "string"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "GtoPdb target family name (e.g. '5-Hydroxytryptamine receptors').",
      "title": "Target Family"
    },
    "hgnc_symbol": {
      "anyOf": [
        {
          "type": "string"
        },
        {
          "type": "null"
        }
      ],
      "default": null,
      "description": "HGNC gene symbol for the human target (e.g. 'HTR2A').",
      "title": "Hgnc Symbol"
    },
    "ligands": {
      "description": "Ligands for this target, filtered and sorted by affinity.",
      "items": {
        "$ref": "#/$defs/IUPHARLigand"
      },
      "title": "Ligands",
      "type": "array"
    },
    "source": {
      "default": "IUPHAR/BPS Guide to Pharmacology",
      "description": "Data source identifier.",
      "title": "Source",
      "type": "string"
    },
    "not_found": {
      "default": false,
      "description": "True if the target name could not be resolved in GtoPdb.",
      "title": "Not Found",
      "type": "boolean"
    },
    "took_ms": {
      "description": "Wall-clock time for all upstream API calls.",
      "title": "Took Ms",
      "type": "integer"
    }
  },
  "required": [
    "target_name",
    "took_ms"
  ],
  "title": "ForgeIUPHARPharmacologyOut",
  "type": "object"
}

curl snippet

Replace $SCIDEX_JWT with a valid bearer token. Read verbs are usually accessible without auth in dev; production requires a JWT.

curl -sS -X POST '/api/scidex/forge/iuphar_pharmacology' \
  -H 'authorization: Bearer $SCIDEX_JWT' \
  -H 'content-type: application/json' \
  -d '{
  "target_name": ""
}'

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