Why have antioxidant approaches consistently failed in tauopathies despite oxidative stress involvement?

clinical neuroscience open
Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
—
Novelty
—
Mechanistic
—
Druggability
—
Priority
70%
Importance
—
Tractability
—
Market price
50%

Description

Multiple clinical trials of antioxidants failed in PSP/CBD, yet oxidative stress clearly contributes to neurodegeneration. The mechanistic disconnect between oxidative damage and therapeutic intervention remains unexplained.

Source: Debate session sess_sda-2026-04-01-gap-005 (Analysis: sda-2026-04-01-gap-005)