What are the long-term toxicity effects of sustained TFEB overactivation in neurons?

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Composite

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Novelty

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Druggability

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Priority

80%

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Tractability

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Market price

50%

Description

The skeptic raised concerns about chronic TFEB activation potentially causing lysosomal storage disorders, but no safety data was provided. This safety profile is essential before therapeutic development can proceed.

Source: Debate session sess_SDA-2026-04-10-gba-pd (Analysis: gba-pd)