Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
75%
Importance
Tractability
Market price
50%

Description

The Skeptic highlighted that TREM2 expression spans multiple myeloid cells beyond microglia, questioning CNS specificity claims. The debate didn’t resolve whether mTOR targeting would selectively benefit microglia or cause off-target effects in other brain cells.

Source: Debate session sess_SDA-2026-04-08-gap-debate-20260406-062033-fecb8755 (Analysis: SDA-2026-04-08-gap-debate-20260406-062033-fecb8755)