Can TFEB chronic activation cause lysosomal storage dysfunction that counteracts therapeutic benefits?

While TFEB activation was proposed to enhance lysosomal clearance, the skeptic raised concerns about chronic overactivation leading to cellular stress. The long-term consequences of sustained TFEB enhancement remain unexplored.

Source: Debate session sess_sda-2026-04-01-002 (Analysis: sda-2026-04-01-002)