Can systemic CD38 activation be achieved without triggering pro-inflammatory responses that accelerate neurodegeneration?

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Composite

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Novelty

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Mechanistic

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Druggability

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Priority

70%

Importance

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Tractability

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Market price

50%

Description

CD38’s pleiotropic effects on NAD+ homeostasis, calcium signaling, and immune responses create therapeutic challenges. The debate identified this as a critical safety concern but provided no resolution for selective activation strategies.

Source: Debate session sess_sda-2026-04-01-gap-v2-89432b95 (Analysis: sda-2026-04-01-gap-v2-89432b95)