What is the optimal sampling frequency for CSF lactate/pyruvate ratios to detect therapeutic response?

biomarker-development open
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Description

While CSF lactate/pyruvate dynamics were identified as promising biomarkers, the debate didn’t resolve the temporal kinetics needed to distinguish therapeutic response from disease progression. The 4-8 week timeline mentioned lacks empirical validation.

Source: Debate session sess_SDA-2026-04-04-SDA-2026-04-04-gap-debate-20260403-222618-c698b06a (Analysis: SDA-2026-04-04-gap-debate-20260403-222618-c698b06a)