Can lysosomal membrane stabilizers selectively prevent tau seeding without disrupting normal autophagy?

While tau-induced lysosomal damage promotes seeding, the therapeutic hypothesis assumes membrane stabilization won’t impair essential lysosomal dynamics. This selectivity has not been demonstrated experimentally.

Source: Debate session sess_SDA-2026-04-03-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-03-gap-tau-prop-20260402003221)