Description
The debate noted that TREM2 loss-of-function increases AD risk, but questioned whether enhancement would be therapeutic due to potential non-linear relationships. The optimal level of microglial activation for therapeutic benefit remains undefined.
Source: Debate session sess_SDA-2026-04-03-gap-seaad-v4-20260402065846 (Analysis: SDA-2026-04-03-gap-seaad-v4-20260402065846)