How can TREM2 agonists be delivered specifically to disease-associated microglia versus homeostatic microglia?

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78%

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50%

Description

While TREM2 modulation showed promise, the debate didn’t address cell-state specificity - a critical gap since homeostatic microglia may require different signaling than pathological DAM states. This selectivity is essential for therapeutic safety.

Source: Debate session sess_SDA-2026-04-02-gap-seaad-v2-20260402032945 (Analysis: SDA-2026-04-02-gap-seaad-v2-20260402032945)