What determines the GPX4/ACSL4 balance that switches microglia from protective to ferroptotic states?

immunology partially_addressed
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Composite
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88%
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Market price
50%

Description

While ACSL4-driven ferroptosis was strongly supported, the molecular triggers that tip the balance from protective GPX4 activity to pathological ACSL4-mediated vulnerability remain unclear. This balance point could be a critical therapeutic target.

Source: Debate session sess_SDA-2026-04-02-gap-seaad-v4-20260402065846 (Analysis: SDA-2026-04-02-gap-seaad-v4-20260402065846)