What determines context-dependent C1q binding outcomes at synapses?

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50%

Description

The skeptic noted that C1q binding doesn’t always lead to synaptic elimination and that ‘context and co-signals matter significantly.’ The molecular determinants of when C1q binding triggers pruning versus protection remain undefined.

Source: Debate session sess_SDA-2026-04-01-gap-v2-691b42f1 (Analysis: SDA-2026-04-01-gap-v2-691b42f1)