How can complement inhibitors be selectively targeted to senescent cell microenvironments without impairing systemic immune surveillance?

While complement-mediated synapse elimination was well-supported, the debate did not resolve the critical challenge of achieving spatial selectivity. This technical gap is essential for therapeutic development to avoid immunosuppression.

Source: Debate session sess_SDA-2026-04-01-gap-013 (Analysis: SDA-2026-04-01-gap-013)