Does transglutaminase-2 cross-linking occur during initial cross-seeding or only after aggregate maturation?

The synthesizer identified TG2 as a promising target but noted uncertainty about whether cross-linking drives cross-seeding initiation or stabilizes existing aggregates. This timing distinction determines whether TG2 inhibition can prevent versus only slow cross-seeding.

Source: Debate session sess_SDA-2026-04-01-gap-9137255b (Analysis: SDA-2026-04-01-gap-9137255b)