Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
75%
Importance
Tractability
Market price
50%

Description

The MAP6 enhancement hypothesis assumes other MAPs can functionally replace tau, but this compensation mechanism remains unproven in disease contexts. Resolving this would validate or refute tau-bypass therapeutic strategies.

Source: Debate session sess_SDA-2026-04-01-gap-004 (Analysis: SDA-2026-04-01-gap-004)