Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adaptation?

The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthesis, suggesting the lipid binding deficit may be compensatory rather than harmful. This fundamental mechanistic question affects all lipid-based therapeutic approaches.

Source: Debate session sess_SDA-2026-04-01-gap-auto-fd6b1635d9 (Analysis: SDA-2026-04-01-gap-auto-fd6b1635d9)