What are the specific cellular targets that arginine-rich DPRs bind to disrupt normal phase separation?

molecular-biology open composite 70%
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Composite
70%
Novelty
70%
Mechanistic
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Druggability
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Priority
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Importance
90%
Tractability
75%
Market price
50%

Description

While DPR competitive inhibitors scored highest therapeutically, the debate didn’t identify the actual molecular targets these peptides bind. Without knowing these targets, rational drug design remains impossible.

Source: Debate session sess_SDA-2026-04-11-sda-2026-04-01-gap-006 (Analysis: SDA-2026-04-11-sda-2026-04-01-gap-006)