Which caspase isoforms specifically cleave tau at Asp-421 in human AD brain tissue?

molecular-biology open composite 62%
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Composite
62%
Novelty
65%
Mechanistic
—
Druggability
—
Priority
80%
Importance
75%
Tractability
80%
Market price
50%

Description

While D421 truncation was identified as disease-specific and therapeutically accessible, the debate did not establish which caspases are responsible in vivo. This knowledge is essential for selective inhibitor development.

Source: Debate session sess_SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd_20260412-091505 (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-1e8eb3bd)