Which synaptic adhesion molecules are necessary and sufficient for tau uptake?

molecular-biology open composite 70%
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Composite
70%
Novelty
78%
Mechanistic
—
Druggability
—
Priority
79%
Importance
88%
Tractability
82%
Market price
50%

Description

The debate identified several candidate proteins (NCAM1, neuroligin-1, N-cadherin) but didn’t establish which are required for pathological tau internalization versus normal synaptic function. This mechanistic gap limits development of selective intervention targets.

Source: Debate session sess_SDA-2026-04-04-gap-tau-prop-20260402003221_20260412-085642 (Analysis: SDA-2026-04-04-gap-tau-prop-20260402003221)