Can mitochondria within extracellular vesicles retain respiratory competence after EV biogenesis and transfer?

cell-biology open composite 65%
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Composite
65%
Novelty
70%
Mechanistic
—
Druggability
—
Priority
85%
Importance
75%
Tractability
85%
Market price
50%

Description

The EV hypothesis assumes functional mitochondrial delivery, but the vesicle packaging process may damage mitochondrial membranes or disrupt electron transport complexes. Functional validation using oxygen consumption assays in recipient neurons is missing.

Source: Debate session sess_sda-2026-04-01-gap-20260401231108_20260412-084542 (Analysis: sda-2026-04-01-gap-20260401231108)