Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
70%
Novelty
70%
Mechanistic
Druggability
Priority
75%
Importance
90%
Tractability
75%
Market price
50%

Description

The skeptic identified this as a universal weakness across all hypotheses - none adequately explain the preferential targeting of cholinergic neurons. Understanding this selectivity is crucial for developing protective therapies.

Source: Debate session sess_SDA-2026-04-16-gap-pubmed-20260411-082446-2c1c9e2d (Analysis: SDA-2026-04-16-gap-pubmed-20260411-082446-2c1c9e2d)