What determines AhR ligand specificity for TMAO versus other gut metabolites in enteric neurons?

molecular-biology open composite 61%
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Composite
61%
Novelty
70%
Mechanistic
—
Druggability
—
Priority
80%
Importance
65%
Tractability
80%
Market price
50%

Description

The skeptic noted AhR is promiscuous with dozens of ligands, but the mechanistic specificity of TMAO-AhR signaling remains unestablished. Understanding competitive binding and pathway selectivity is essential for therapeutic targeting.

Source: Debate session sess_SDA-2026-04-16-gap-20260416-121711_20260416-134918 (Analysis: SDA-2026-04-16-gap-20260416-121711)