Can lysosomal dysfunction convert tau into proteolysis-resistant conformations that propagate independently?

cell-biology open composite 70%
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Composite
70%
Novelty
80%
Mechanistic
—
Druggability
—
Priority
79%
Importance
88%
Tractability
75%
Market price
50%

Description

The hypothesis that Aβ-mediated lysosomal damage creates self-propagating tau seeds was proposed but remains mechanistically unvalidated. This gap prevents development of autophagy-enhancing therapeutics and understanding of tau strain diversity in AD.

Source: Debate session sess_SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974_20260416-134419 (Analysis: SDA-2026-04-16-gap-pubmed-20260410-180503-a7a03974)