Can C1q-mediated synaptic pruning be blocked without impairing Aβ clearance functions?

immunology open composite 72%
Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
72%
Novelty
80%
Mechanistic
—
Druggability
—
Priority
80%
Importance
92%
Tractability
75%
Market price
50%

Description

Multiple hypotheses assume these functions are separable, but the debate revealed conflicting evidence about whether the same C1q protein mediates both processes through overlapping mechanisms. Resolving this is critical for therapeutic selectivity.

Source: Debate session sess_SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1 (Analysis: SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1)