What are the druggable differences between C1q binding interfaces for neuronal membranes versus Aβ?

molecular-biology open composite 65%
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Composite
65%
Novelty
70%
Mechanistic
—
Druggability
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Priority
75%
Importance
80%
Tractability
85%
Market price
50%

Description

Hypothesis 2 proposed targeting distinct C1q binding domains, but the debate did not establish whether these interfaces are structurally distinct enough for selective inhibition. This structural biology gap limits rational drug design approaches.

Source: Debate session sess_SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1 (Analysis: SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1)