What are the downstream signaling pathways linking ARF6/exocyst to VE-cadherin trafficking?

Open a bounty challenge Fund this gap and accept submissions. SPEC-033.

Composite

—

Novelty

—

Mechanistic

—

Druggability

—

Priority

56%

Importance

70%

Tractability

80%

Market price

50%

Description

While ARF6 and exocyst complex are identified as VE-cadherin interactors involved in trafficking and recycling, the specific signaling cascades and regulatory mechanisms remain undefined. This limits understanding of how junctional remodeling is precisely controlled.

Gap type: unexplained_observation Source paper: Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion. (2024, Nat Commun, PMID:39232006)