Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
74%
Importance
78%
Tractability
72%
Market price
50%

Description

The discovery of an mCH signature identifying genes escaping X-chromosome inactivation is novel but mechanistically unexplained. This gap is important for understanding sex-linked neurological disorders and X-linked intellectual disabilities.

Gap type: unexplained_observation Source paper: Global epigenomic reconfiguration during mammalian brain development. (2013, Science, PMID:23828890)