Description
The abstract shows that removing canonical E2F activators increases genome ploidy in endocycling cells, yet these same factors coordinate G2/M programs critical for mitosis. This paradoxical relationship between mitotic promotion and endocycle regulation lacks mechanistic explanation.
Gap type: contradiction Source paper: Canonical and atypical E2Fs regulate the mammalian endocycle. (2013, Nature cell biology, PMID:23064266)