Description
The study identifies a ~0.9-Mb inversion creating two differentiated haplotypes associated with severe COVID-19, but the functional mechanisms linking this structural variant to disease severity remain unexplained. Understanding this mechanism could reveal new therapeutic targets for severe respiratory failure.
Gap type: unexplained_observation Source paper: Detailed stratified GWAS analysis for severe COVID-19 in four European populations. (2022, Human molecular genetics, PMID:35848942)