Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
76%
Importance
70%
Tractability
80%
Market price
50%

Description

The abstract reports decreased HDAC2 levels specifically, but the mechanism for this selective reduction is unexplained. Understanding this selectivity is important since different HDAC isoforms have distinct roles in neuronal function and disease.

Gap type: unexplained_observation Source paper: Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways. (None, None, PMID:27735126)