What is the direct molecular mechanism linking aconitine exposure to AMPK phosphorylation inhibition?

neurotoxicology open
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Description

The study shows aconitine reduces AMPK phosphorylation and that AMPK activation rescues the phenotype, but the direct molecular pathway connecting aconitine to AMPK inhibition remains unexplained. Understanding this mechanism is crucial for developing targeted neuroprotective strategies against aconitine toxicity.

Gap type: unexplained_observation Source paper: Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells. (2021, Toxicology letters, PMID:33945864)