Description
The study demonstrates BBB crossing but doesn’t elucidate the transport mechanisms involved. This knowledge gap limits optimization of delivery efficiency and understanding of EV biodistribution in the CNS.
Gap type: unexplained_observation Source paper: Engineered MSC-EVs loaded with BDNF-enhancing neuropeptides via a non-disruptive method enhance post-stroke neuroregeneration via intranasal delivery. (None, None, PMID:40883738)