Description
While CX43 inhibition alleviates chemoresistance, the mechanistic link between gap junction communication and STAT1 pathway activation remains unclear. This gap limits understanding of how astrocyte-tumor cell crosstalk drives therapeutic resistance in brain metastases.
Gap type: unexplained_observation Source paper: Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Through CX43 Dependent STAT1 Signaling in Co-Culture Spheroids. (2026, Biotechnol Bioeng, PMID:41486609)