Description
The study only tested paclitaxel, leaving unknown whether CX43-STAT1 mediated protection is drug-specific or represents a general resistance mechanism. This knowledge gap affects the broader applicability of targeting this pathway for brain metastasis treatment.
Gap type: open_question Source paper: Astrocytes Protect Brain Metastatic Breast Cancer Cells From Chemotherapy Through CX43 Dependent STAT1 Signaling in Co-Culture Spheroids. (2026, Biotechnol Bioeng, PMID:41486609)