Description
The authors acknowledge that molecular profiles of iPSC-PC under hypoxic conditions remain largely unexplored. This knowledge gap is essential for validating iPSC-PC as faithful models of endogenous pericytes and predicting their therapeutic efficacy in ischemic conditions.
Gap type: open_question Source paper: Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia. (2025, Stem cells (Dayton, Ohio), PMID:40737487)