Description
The authors demonstrate that two serotonin signaling modulators can ameliorate gut dysmotility in DYRK1A-perturbed models, but the mechanistic basis for this rescue is not explained. This gap limits the rational development of serotonin-based therapeutics for autism-associated GI issues.
Gap type: unexplained_observation Source paper: Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility. (None, None, PMID:40050271)