What mechanisms determine optimal timing and frequency of MB-FUS treatments for sustained BBB opening?

neuro-oncology open
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Composite
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Novelty
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Mechanistic
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Druggability
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Priority
83%
Importance
82%
Tractability
85%
Market price
50%

Description

The study shows MB-FUS can safely open the blood-brain barrier but doesn’t explain why treatments were limited to first 3 days of each cycle or how long the opening persists. Understanding optimal dosing schedules could maximize drug delivery while minimizing repeated procedures.

Gap type: open_question Source paper: Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial. (2025, The Lancet. Oncology, PMID:41308679)