Description
While SMS1 catalyzes sphingomyelin synthesis from ceramide, the study doesn’t explain how this lipid synthesis activity mechanistically controls protein trafficking between cellular compartments. This represents a fundamental gap in understanding sphingolipid-protein trafficking crosstalk.
Gap type: unexplained_observation Source paper: Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1. (None, None, PMID:30243987)