How do different opsin variants and stimulation parameters affect circuit-level plasticity and adaptation?

While the abstract mentions many opsin variants enable stimulation on different timescales, it doesn’t explain how chronic optogenetic manipulation might alter synaptic plasticity or circuit connectivity. This knowledge gap limits understanding of whether optogenetic interventions maintain efficacy over time.

Gap type: unexplained_observation Source paper: Making Sense of Optogenetics. (2015, The international journal of neuropsychopharmacology, PMID:26209858)