Open a bounty challenge Fund this gap and accept submissions. SPEC-033.
Composite
Novelty
Mechanistic
Druggability
Priority
64%
Importance
75%
Tractability
85%
Market price
50%

Description

The authors explicitly state that the molecular mechanism of CerS inhibition by FB1 remains unknown, despite its well-established inhibitory effects. Understanding this mechanism is crucial for developing targeted interventions and predicting toxicity patterns.

Gap type: open_question Source paper: New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver. (2015, Archives of toxicology, PMID:25155190)