Description
The abstract highlights dose-limiting thrombocytopenia and hemotoxicity as specific challenges for cereblon-based degraders, requiring transgenic models for evaluation. The mechanistic basis for why this E3 ligase pathway specifically affects hematopoietic cells remains unexplained, limiting rational design of safer degraders.
Gap type: unexplained_observation Source paper: Session 5: Protein Degraders. (2024, Toxicologic pathology, PMID:39660628)