Description
The study reveals that H3K27M gliomas contain predominantly OPC-like cells with a minority of differentiated malignant cells, but the mechanisms controlling this cellular heterogeneity and population dynamics are not addressed. This knowledge gap limits understanding of tumor evolution and therapeutic resistance.
Gap type: unexplained_observation Source paper: Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. (2018, Science (New York, N.Y.), PMID:29674595)