Description
While PDGFRA signaling is identified as sustaining OPC-like cells, the mechanistic details of how this pathway maintains the undifferentiated state and prevents normal oligodendrocyte maturation are not explained. Understanding this could reveal differentiation-based therapeutic approaches.
Gap type: unexplained_observation Source paper: Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. (2018, Science (New York, N.Y.), PMID:29674595)