Description
The abstract notes these gliomas arise primarily in midline CNS structures of young children, suggesting cooperation between genetics and cellular context. However, the specific mechanisms explaining this anatomical and developmental selectivity remain unexplained, limiting understanding of tumor initiation.
Gap type: unexplained_observation Source paper: Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. (2018, Science (New York, N.Y.), PMID:29674595)