Description
The study shows that 75-85% of synaptic tau lacks its C-terminus, but the specific proteases and pathways responsible for this selective cleavage at synapses remain unknown. Understanding this mechanism is critical since C-terminal truncation may facilitate both tau aggregation and trans-synaptic spread in AD.
Gap type: unexplained_observation Source paper: Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer’s disease. (2015, Journal of neurochemistry, PMID:25393609)