Description
The study reveals a striking compartmentalization where neuroinflammatory markers are detectable in extracellular vesicles but absent from plasma in COVID-19 survivors. This selective packaging suggests unknown EV-specific mechanisms that could be critical for understanding PASC pathophysiology and developing targeted diagnostics.
Gap type: unexplained_observation Source paper: SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles. (2025, Frontiers in immunology, PMID:40330474)