Description
Decreased IDO expression in dendritic cells is observed alongside neurofilament elevation, but whether this immune metabolic dysfunction directly contributes to neurodegeneration or is merely correlative is unknown. This gap is critical since IDO regulates tryptophan metabolism and neuroinflammation.
Gap type: unexplained_observation Source paper: SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles. (2025, Frontiers in immunology, PMID:40330474)