Description
The authors conclude that PEL24-199 works ‘via a neuroinflammatory-dependent process’ but don’t identify which inflammatory mediators or pathways are involved. This mechanistic gap limits understanding of how to optimize anti-inflammatory approaches in AD.
Gap type: unexplained_observation Source paper: A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APP (2023, International journal of molecular sciences, PMID:36982363)