Description
The abstract shows BM cells can engraft in brain and become microglia-like under myeloablative conditions, but the molecular mechanisms governing this transdifferentiation are not explained. Understanding this process is critical for optimizing cellular delivery strategies for neurodegeneration.
Gap type: unexplained_observation Source paper: Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice. (2014, Laboratory investigation; a journal of technical methods and pathology, PMID:25199051)